Toledo Lab Publications
For a full list of publications, click here.
- Author Correction: Dynamic changes of muscle insulin sensitivity after metabolic surgeryby Sofiya Gancheva on June 10, 2022 at 10:00 am
- Insulin and glucose metabolism with olanzapine and a combination of olanzapine and samidorphan: exploratory phase 1 results in healthy volunteersby Frederico G S Toledo on December 10, 2021 at 11:00 am
A combination of olanzapine and samidorphan (OLZ/SAM) received US Food and Drug Administration approval in May 2021 for the treatment of adults with schizophrenia or bipolar I disorder. OLZ/SAM provides the efficacy of olanzapine, while mitigating olanzapine-associated weight gain. This exploratory study characterized the metabolic profile of OLZ/SAM in healthy volunteers to gain mechanistic insights. Volunteers received once-daily oral 10 mg/10 mg OLZ/SAM, 10 mg olanzapine, or placebo for 21...
- The relationship between pre-existing diabetes mellitus and the severity of acute pancreatitis: Report from a large international registryby Pedram Paragomi on October 17, 2021 at 10:00 am
CONCLUSION: About one in 5 patients with AP have pre-existing DM. Once confounding risk factors are considered, pre-existing DM per se is not a risk factor for severe AP.
- Weight Loss and Exercise Differentially Affect Insulin Sensitivity, Body Composition, Cardiorespiratory Fitness, and Muscle Strength in Older Adults With Obesity: A Randomized Controlled Trialby Andrea M Brennan on August 18, 2021 at 10:00 am
CONCLUSIONS: Exercise with weight loss improved insulin sensitivity and VO2peak, decreased ectopic fat, and preserved lean mass and strength. Weight loss alone decreased lean mass and strength. Older adults intending to lose weight should perform regular exercise to promote cardiometabolic and functional benefits, which may not occur with calorie restriction-induced weight loss alone.
- Understanding the Contribution of Insulin Resistance to the Risk of Pancreatic Cancerby Frederico G S Toledo on May 13, 2021 at 10:00 am
Type 2 diabetes is a known risk factor for the development of pancreatic adenocarcinoma. However, the mechanisms behind this epidemiological association remain unclear. Whether it is hyperglycemia or insulin resistance that increases the risk of pancreatic adenocarcinoma is a question that has yet to be settled. A new study by Kim et al published in The American Journal of Gastroenterology shows that the presence of insulin resistance independently increases pancreatic cancer mortality even in...