Toledo Lab Publications
For a full list of publications, click here.
- Dual Roles of Cardiorespiratory Fitness and Fatigability in the Life-Space Mobility of Older Adults: The Study of Muscle Mobility and Aging (SOMMA)by Kyle D Moored on January 30, 2023 at 11:00 am
CONCLUSION: Fitness below a critically low threshold was associated with limited life-space mobility, suggesting that certain older individuals may need to operate close to their maximum aerobic capacity to traverse daily environments; these associations were driven by those with more severe physical fatigability.
- Mitochondrial energetics in skeletal muscle are associated with leg power and cardiorespiratory fitness in the Study of Muscle, Mobility, and Aging (SOMMA)by Theresa Mau on December 3, 2022 at 11:00 am
CONCLUSIONS: Higher muscle mitochondrial energetics measures were associated with both better cardiorespiratory fitness and greater leg power in older adults. Muscle mitochondrial energetics explained a greater degree of variance in VO2 peak compared to leg power.
- A reduced pancreatic polypeptide response is associated with new onset pancreatogenic diabetes versus type 2 diabetesby Phil A Hart on November 20, 2022 at 11:00 am
CONCLUSIONS: Fasting PP concentrations and the response to meal stimulation are reduced in new onset DM associated with PDAC or CP compared to T2DM. These findings support further investigations into the use of PP concentrations to characterize pancreatogenic DM, and to understand the pathophysiological role in exocrine pancreatic diseases. (NCT03460769).
- Type 1 Diabetes in Acute Pancreatitis Consortium: From Concept to Realityby Jose Serrano on October 7, 2022 at 10:00 am
Acute pancreatitis (AP), resulting from inflammation of the pancreas, accounts for more than 300,000 US hospital discharges per year. Although glucose intolerance has been known as a complication of severe AP, this effect was thought to be transient. Recently, cohort studies and meta-analysis of 24 published studies of 1100 patients who survived one or more episodes of AP revealed that 30% to 40% of patients developed diabetes or impaired glucose tolerance within 3 to 4 years of even a single...
- Rationale and Design for the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study: A Prospective Cohort Study From the Type 1 Diabetes in Acute Pancreatitis Consortiumby Phil A Hart on October 7, 2022 at 10:00 am
Acute pancreatitis (AP) is a disease characterized by an acute inflammatory phase followed by a convalescent phase. Diabetes mellitus (DM) was historically felt to be a transient phenomenon related to acute inflammation; however, it is increasingly recognized as an important late and chronic complication. There are several challenges that have prevented precisely determining the incidence rate of DM after AP and understanding the underlying mechanisms. The DREAM (Diabetes RElated to Acute...